WebJun 13, 2013 · This critical process temperature is the collapse temperature for amorphous substance, or eutectic melt for the crystalline substance1,9,10.During freezing, ice crystals start separating out until the solution becomes maximally concentrated. On further cooling, phase separation of the solute and ice takes place. WebCrystalline bulking agents such as mannitol provide good appearance and cake structure but may not be compatible with complex formulations such as …
Microcrystalline cellulose - Wikipedia
WebApr 1, 2011 · Freezing the typical protein formulation results in two phases: about 80% of the frozen solution consists of crystals of pure ice and the remaining 20% is an amorphous or partially crystalline phase that contains all the excipients and protein (concentrated about 5X) along with some amorphous water left behind after the ice crystals have formed … WebJan 5, 2024 · CCTV cameras are a great way to save money for your business! They can help you save on insurance, reduce crime and other expenses. CCTV cameras can also … merit fitness 715t plus treadmill review
Lyophilization Cycle Development for a High ... - ScienceDirect
WebJun 1, 2007 · Inclusion of a crystalline bulking agent may allow for primary drying with a product temperature above the T g ′ of the amorphous components of that formulation. Collapse of the amorphous phase onto and within the structural support provided by the crystalline bulking agent (or micro‐collapse) may be acceptable providing product … WebFeb 19, 2014 · Bulking agents are also added to lyophilised product to prevent product ‘blowout’ for low concentration product (≤ 1% solid), increase the product collapse temperature and/or to improve product elegance. ... raffinose, dextran, hydroxyethyl starch (HES)) or crystalline bulking agents (e.g. glycine, mannitol). Excipients with high glass ... WebNov 1, 2024 · Bulking agent Crystallization Sucrose Protein stability Glass transition Collapse Abbreviations AA amino acid AU absorbance unit aFD after freeze-drying API … merit fitness 715t treadmill mobile wheel