Witryna1 sty 2002 · The mechanistic link between effects on the HERG potassium channel with consecutive QT-prolongation and the resulting ventricular arrhythmias appears to be … Witryna7 lip 1995 · In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been …
hERG - Wikipedia
Witryna8 cze 2024 · The rapidly activating delayed rectifier K+ current generated by the cardiac hERG potassium channel encoded by KCNH2 is the most important reserve current … WitrynaIntroduction: The aim of this study was to analyze the block of HERG-carried membrane currents caused by H 345/52, a new antiarrhythmic compound with low proarrhythmic … reformation zelda dress
UChicago Medicine research reveals intriguing theory on hERG …
hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Zobacz więcej hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Zobacz więcej A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by electron microscopy. In the laboratory the Zobacz więcej This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Zobacz więcej The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Zobacz więcej Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem from ion channel dysfunction (so-called channelopathies) that can lead … Zobacz więcej Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment of a cardiac safety profile during pre-clinical drug development: ICH S7B. The … Zobacz więcej HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Zobacz więcej Witryna1 wrz 2010 · Introduction. There has been a great deal of interest in manipulating human ether-á-go-go related gene (hERG) potassium channel function since the important … Witryna29 lut 2016 · The human ether-a-go-go related gene (hERG) plays an important role in cardiac action potential. It encodes an ion channel protein named Kv11.1, which is … reformation zaria dress